Antibiotics Are Man's Greatest Invention

Month: September 2019

Engineering nucleoside antibiotics toward the development of novel antimicrobial agents

Bridge of nose pain: Causes and how to treat it

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Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

Reports Offer Valuable Information on Antibiotic Stewardship in U.S. Agriculture

In May, the U.S. Department of Agriculture released new data on the use of antibiotics in U.S. operations that raise swine or feedlot cattle—information that provides crucial insights into antibiotic stewardship practices, helps identify areas for improvement, and guides policy efforts to combat antibiotic resistance….

Auditory Evoked Responses in Older Adults With Normal Hearing, Untreated, and Treated Age-Related Hearing Loss

Objectives: The goal of this study was to identify the effects of auditory deprivation (age-related hearing loss) and auditory stimulation (history of hearing aid use) on the neural registration of sound across two stimulus presentation conditions: (1) equal sound pressure level and (2) equal sensation level. Design: We used a between-groups design, involving three groups of 14 older adults (n = 42; 62 to 84 years): (1) clinically defined normal hearing (≤25 dB from 250 to 8000 Hz, bilaterally), (2) bilateral mild–moderate/moderately severe sensorineural hearing loss who have never used hearing aids, and (3) bilateral mild–moderate/moderately severe sensorineural hearing loss who have worn bilateral hearing aids for at least the past 2 years. Results: There were significant delays in the auditory P1-N1-P2 complex in older adults with hearing loss compared with their normal hearing peers when using equal sound pressure levels for all participants. However, when the degree and configuration of hearing loss were accounted for through the presentation of equal sensation level stimuli, no latency delays were observed. These results suggest that stimulus audibility modulates P1-N1-P2 morphology and should be controlled for when defining deprivation and stimulus-related neuroplasticity in people with hearing loss. Moreover, a history of auditory stimulation, in……

Foods to eat and avoid with the flu

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Pew Thanks Congress for Introducing Bill to Spur Antibiotic Development

The Pew Charitable Trusts sent a letter to Representatives Danny K. Davis (D-IL) and Kenny Marchant (R-TX) on Aug. 1 thanking them for introducing the Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms (DISARM) Act of 2019 in the House….

Synergistic antifungal interactions of amphotericin B with 4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol

Effects of Reverberation on the Relation Between Compression Speed and Working Memory for Speech-in-Noise Perception

Objectives: Previous study has suggested that when listening in modulated noise, individuals benefit from different wide dynamic range compression (WDRC) speeds depending on their working memory ability. Reverberation reduces the modulation depth of signals and may impact the relation between WDRC speed and working memory. The purpose of this study was to examine this relation across a range of reverberant conditions. Design: Twenty-eight older listeners with mild-to-moderate sensorineural hearing impairment were recruited in the present study. Individual working memory was measured using a Reading Span test. Sentences were combined with noise at two signal to noise ratios (2 and 5 dB SNR), and reverberation was simulated at a range of reverberation times (0.00, 0.75, 1.50, and 3.00 sec). Speech intelligibility was measured in listeners when listening to the sentences processed with simulated fast-acting and slow-acting WDRC conditions. Results: There was a significant relation between WDRC speed and working memory with minimal or no reverberation. Consistent with previous research, this relation was such that individuals with high working memory had higher speech intelligibility with fast-acting WDRC, and individuals with low working memory performed better with slow-acting WDRC. However, at longer reverberation times, there was no relation between WDRC speed and working memory. Conclusions:……

Metabolic state matters for antibiotic lethality