Antibiotics Are Man's Greatest Invention

Category: General

Engineering nucleoside antibiotics toward the development of novel antimicrobial agents

Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

Reports Offer Valuable Information on Antibiotic Stewardship in U.S. Agriculture

In May, the U.S. Department of Agriculture released new data on the use of antibiotics in U.S. operations that raise swine or feedlot cattle—information that provides crucial insights into antibiotic stewardship practices, helps identify areas for improvement, and guides policy efforts to combat antibiotic resistance….

Pew Thanks Congress for Introducing Bill to Spur Antibiotic Development

The Pew Charitable Trusts sent a letter to Representatives Danny K. Davis (D-IL) and Kenny Marchant (R-TX) on Aug. 1 thanking them for introducing the Developing an Innovative Strategy for Antimicrobial Resistant Microorganisms (DISARM) Act of 2019 in the House….

Synergistic antifungal interactions of amphotericin B with 4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol

Metabolic state matters for antibiotic lethality

Antibiotics Currently in Global Clinical Development

As of September 2017, an estimated 48 new antibiotics with the potential to treat serious bacterial infections are in clinical development. The success rate for clinical drug development is low; historical data show that, generally, only 1 in 5 infectious disease products that enter human testing (phase 1 clinical trials) will be approved for patients….

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

Nontraditional Products for Bacterial Infections in Clinical Development

As of September 2017, an estimated 33 new nontraditional products with the potential to treat or prevent serious bacterial infections are in clinical development. Below is a snapshot of the current nontraditional products pipeline, based on publicly available information and informed by external experts….

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases